UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 14A

                                 (Rule 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION

           PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES
                              EXCHANGE ACT OF 1934
                                (Amendment No. )

Filed by the registrant [X]

Filed by a party other than the registrant [ ]

Check the appropriate box:

[ ]   Preliminary proxy statement.

[ ]   Confidential, for use of the Commission only (as permitted by Rule
      14a-6(e)(2)).

[X]   Definitive proxy statement.

[ ]   Definitive additional materials.

[ ]   Soliciting material under Rule 14a-12

                          Third Wave Technologies, Inc.Section 240.14a-12

                          THIRD WAVE TECHNOLOGIES, INC.
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                (Name of Registrant as Specified in Its Charter)


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      (Name of Person(s) Filing Proxy Statement if Other Than the Registrant)

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            pursuant to Exchange Act Rule 0-11 (set forth the amount on which
            the filing fee is calculated and state how it was determined):

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            Act Rule 0-11(a)(2) and identify the filing for which the offsetting
            fee was paid previously. Identify the previous filing by
            registration statement number, or the form or schedule and the date
            of its filing.

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                          THIRD WAVE TECHNOLOGIES, INC.

                                  ---------------------

                      2003------------

                  NOTICE OF 2006 ANNUAL MEETING OF SHAREHOLDERSSTOCKHOLDERS
                            TO BE HELD JUNE 10, 2003
                             ---------------------13, 2006

                                  ------------

To our Shareholders:Stockholders:

     NOTICE IS HEREBY GIVEN that the annual meeting of shareholdersstockholders of Third
Wave Technologies, Inc., a Delaware corporation (the "Company"), will be held at
the offices of the Company, 502 South Rosa Road, Madison, Wisconsin 53719 on
June 10, 200313, 2006, at 9:00 a.m., local time, for the following purposes:

          (1)- To elect threetwo directors each to serve for a term of three years expiring
            uponat the 20062009 annual meeting of shareholdersstockholders or until their
     successors arehis successor is
            elected and qualified;

          (2)- To ratify the appointment of Ernst & YoungGrant Thornton LLP as the independent
            auditorsregistered public accounting firm of the Company for the year ending
            December 31, 2003;2006; and

          (3)- To transact any other business whichthat is properly presented at the
            meeting.

     The foregoing items of business are more fully described in the proxy
statement accompanying this notice. Only shareholdersstockholders of record at the close of
business on April 18, 200314, 2006, are entitled to notice of and to vote at this
meeting.

     All shareholdersstockholders are invited to attend the meeting in person. However, to
assure your representation at the meeting, you are urged to sign and return the
enclosed proxy as promptly as possible in the postage prepaid envelope enclosed
for that purpose. Any shareholderstockholder entitled to vote and attending the meeting may
vote in person even if a proxy is returned.

                                        By Order of the Board of Directors,

                                        /s/ LANCE FORS, PH.D

                                          Lance Fors, Ph.D
                                          Chairman of the BoardKEVIN T. CONROY
                                        KEVIN T. CONROY
                                        President and Chief Executive Officer

April 25, 2003May 5, 2006



                          THIRD WAVE TECHNOLOGIES, INC.



                                  ---------------------------------

                             PROXY STATEMENT FOR THE
                     20032006 ANNUAL MEETING OF THE SHAREHOLDERS
                                 JUNE 10, 2003
                             ---------------------STOCKHOLDERS


                                  ------------

                 INFORMATION CONCERNING SOLICITATION AND VOTING

GENERAL

     The enclosed proxy is solicited on behalf of Third Wave Technologies, Inc.
(the "Company", "us", "we", "our" or "our""Third Wave") for use at the annual meeting
of shareholdersstockholders to be held on Tuesday, June 10, 200313, 2006, at 9:00 a.m., local time,
or at any adjournment or adjournments thereof, for the purposes set forth herein
and in the accompanying notice of annual meeting of shareholders.stockholders. The annual
meeting will be held at the principal executive offices of the Company at 502
South Rosa Road, Madison, Wisconsin 53719. The telephone number at that location
is (608) 273-8933.

     These proxy solicitation materials are being mailed on or about April 25,
2003May 5,
2006, to all shareholdersstockholders entitled to vote at the meeting.

RECORD DATE

     ShareholdersStockholders of record at the close of business on April 18, 2003,14, 2006, the
record date for the meeting, are entitled to notice of and to vote at the
meeting. At the record date, 39,578,77441,404,827 shares of the Company's common stock
were issued and outstanding.

REVOCABILITY OF PROXIES

     Any proxy given pursuant to this solicitation may be revoked by the person
giving it at any time before its use by delivering to the Company a duly
executed proxy bearing a later date, by attending the shareholderstockholder meeting and
voting in person, or by delivering to the Secretary of the Company, at the
Company's principal executive offices, a written notice of revocation.

VOTING AND SOLICITATION

     Each shareholderstockholder is entitled to one vote for each share held as of the
record date for the meeting. Shareholders will not be entitled to cumulate their
votes in the election of directors.

     The cost of soliciting proxies will be borne by the Company. The Company
expects to reimburse brokerage firms and other persons representing beneficial
owners of shares for their expenses in forwarding solicitation material to such
beneficial owners. Proxies may also be solicited by certain of the Company's
directors, officers and employees, without additional compensation, personally
or by telephone, telegram,e-mail, facsimile or other means of communication. We have
engaged Georgeson & Co. to assist us in distributing materials for a fee
estimated at $5,000, plus reimbursement of out-of-pocket expenses.

QUORUM; ABSTENTIONS; BROKER NON-VOTES

     Votes castThe presence, either in person or by proxy, or in personof the holders of a majority of
the total outstanding shares of common stock as of the record date will
constitute a quorum at the annual meeting. Abstaining votes and broker non-votes
are counted for purposes of establishing a quorum. A broker non-vote occurs when
a nominee holding shares for a beneficial owner does not vote on a particular
matter because the nominee has not received instructions from the beneficial
owner and does not have discretionary voting power for that particular item.

     In the election of directors, the two director nominees receiving the most
affirmative votes of the shares of common stock present or represented and
entitled to vote at the meeting will be tabulated by
the inspectorelected as directors. The affirmative
vote of elections appointed for the meeting and will determine whether
a quorum is present.

     We need a majority of the shares of common stock issuedpresent or represented and
outstanding onentitled to vote is required to ratify the record date present,selection of Grant Thornton LLP as
the independent public accounting firm to audit the financial statements of the
Company.



     An abstaining vote in person or by proxy, to have a quorum to allow us to
hold the annual meeting. Shares that are voted "For", "Against" or "Abstain"
with respect to any matter are treated as being present at the meeting.


     In the election of directors you can withhold youris not counted and
therefore has no effect on the election; however, an abstaining vote foron all
other proposals will have the same effect as a negative vote on the proposal. A
broker non-vote on any nominee.
Withheld votes will be excluded entirely from the vote onproposal, including the election of directors, and will have no effect on the outcome. On the ratification of the
appointment of Ernst & Young LLP, you can vote to "abstain". If you vote to
"abstain", your vote will have the effect of a vote against the ratification.

     If you hold shares through a broker, follow the voting instructions you
receive from your broker. If you do not submit voting instructions with respect
to a matter and your broker does not vote your shares on that matter (so-called
"broker non-votes"), your shares will not
be countedincluded in determiningthe tabulation of the voting results and therefore does not
affect the outcome of the vote on that matter.vote.

     Any proxy that is returned using the form of proxy enclosed and whichthat is not
marked as to a particular item will be voted for the election of the three
nominees
named in this proxy statement, for the ratification of the appointment of the
independent auditors, as the case may be, with respect to the items not marked,
and as the proxy holders deem advisable on other matters that may come before
the meeting, as the case may be, with respect to
the items not marked.meeting.

DEADLINE FOR RECEIPT OF SHAREHOLDERSTOCKHOLDER PROPOSALS

     Proposals of shareholders that areTo have a proposal intended to be presented by those
shareholders at the Company's annual meetingAnnual Meeting of
Stockholders to be held in 20042007 be considered for inclusion in the Company's
proxy statement and form of proxy relating to that meeting, a stockholder must
be
submitteddeliver written notice of such proposal in writing to the Secretary of the
Company no later than January 7, 2007.

     In addition, the bylaws provide that if a stockholder desires to submit a
proposal for consideration at the Company's executive
offices and received2007 Annual Meeting of Stockholders, or to
nominate persons for election as director at that meeting, or both, the
stockholder must deliver written notice of such proposal or nomination in
writing in the form specified by the bylaws to the Secretary of the Company no
later than December 26, 2003 in order
that those proposals mayJanuary 7, 2007 or such proposal will be considered for possible inclusionuntimely. The
bylaws further provide that the presiding officer of the meeting shall refuse to
acknowledge any untimely proposal or nomination. Additionally, under applicable
SEC rules the persons named in the proxy statement relating to that meeting.

     In addition,and form of proxy for the
by-laws2007 Annual Meeting of the Company provide that any shareholder
entitledStockholders would have discretionary authority to vote
may nominate persons for election as directors or propose
business to be brought before a meeting, or both, only if the shareholder has
given timely notice in proper written form of the shareholder's intent to make aon any such untimely nomination or propose business. To be timely, the shareholder's notice must be
delivered to or mailed and received at the principal executive offices of the
Company not less than 120 days in advance of the first anniversary date of
mailing of the Company's proxy statement released to shareholders in connection
with the previous year's annual meeting of shareholders, unless no annual
meeting was held in the previous year or the date of the annual meeting has been
changed by more than 30 days from the date contemplated at the time of the
previous year's proxy statement, in which case, to be timely such notice must be
so received a reasonable time before the solicitation is made. The by-laws
contain provisions regarding information that must be set forth in the
shareholder's notice in order for it to be in proper form.

                                 PROPOSAL NO. 1proposal.

                              ELECTION OF DIRECTORS

     The Company's board of directors currently consists of nine persons,seven members and is
divided into three classes serving terms of three years. ShareholdersStockholders elect one
class of directors at each annual meeting. ThreeTwo directors are to be elected at
this annual meeting each to hold office until the 20062009 annual meeting of shareholdersstockholders
or until a successor has been duly elected and qualified. The other
classesboard of directors
will be electedhas nominated Gordon Brunner and Lawrence Murphy for re-election as directors.
Mr. Neis, whose term as director expires at the Company's annual meetingsmeeting, has chosen not
to stand for re-election after twelve years of shareholdersservice as a director and the
board has decided not to be held in 2004 and 2005.fill this position at this time.

     If any of the nomineesa nominee for director at the annual meeting becomes unavailable or
declines to serve as a director at the time of the annual meeting, the proxy
holders will vote the proxies in their discretion for any nominee who is
designated by the current board of directors to fill the vacancy. We do notMr. Brunner
and Mr. Murphy each have indicated their continued willingness and desire to
serve as directors and we have no reason to expect any of the nomineesthat either nominee will be
unable to be unavailable to serve.serve as a director if so elected.

     The names of the three nominees for election to the board of directors at the
annual meeting, and the other members of the board of directors, their ages as
of the record date for the meeting, and certain information about them are set
forth below.

                        The names of the current
directors with unexpired terms, their ages as of the record date, and certain
information about them are also stated below.

                                        2


      NOMINEES FOR ELECTION AT THE ANNUAL MEETING FORDIRECTORS - TERMS ENDING IN 2006

NAME AGE PRINCIPAL OCCUPATION - ---- --- --------------------------------------------------------------- John Neis(1)(2)(3)........................ 47 Senior Partner, Venture Investors Management LLC Sam Eletr, Ph.D. ......................... 64Gordon F. Brunner(1) 67 Retired; Former Chairman and CEO of Applied Biosystems. Gordon F. Brunner......................... 64 Partner, Living Longer Proactive Health; retired Senior Vice President, (3)(4)................. Chief Technology Officer, and member of the Board of Directors of Procter & Gamble Co.Company; Partner, Cincinnati Living Longer ProActive Health Center Lawrence Murphy(1)(2).... 63 Independent Business Consultant, former executive vice president and secretary of Core Industries, Inc. John Neis(1)(2).......... 50 Senior Partner, Venture Investors LLC
2 DIRECTORS CONTINUING IN OFFICE - TERMS ENDING IN 20042007
NAME AGE PRINCIPAL OCCUPATION - ---- --- -------------------- Lance Fors, Ph.D.......................... 45 Chairman of the Board,Kevin T. Conroy.......... 40 President and Chief Executive Officer, Third Wave Technologies, Inc. David A. Thompson(3)...................... 61Thompson(1)(3).. 64 Retired; Former Senior Vice President & President, & President, Diagnostic Division, Abbott Laboratories Kenneth R. McGuire........................ 61 Chief Executive Officer, Burbank Group of Companies
DIRECTORS CONTINUING IN OFFICE - TERMS ENDING IN 20052008
NAME AGE PRINCIPAL OCCUPATION - ---- --- -------------------- Tom Daniel(1)(2)(3)....................... 38James Connelly(2)(4)..... 59 Partner, Schroder Ventures G. Steven Burrill(2)...................... 58 Chief Executive Officer, BurrillFoley & Company Lloyd M. Smith, Ph.D.(1)Lardner Lionel Sterling(2)(3)............... 48 Kellett Professor of Chemistry, University of Wisconsin and Member, Scientific Advisory Board, Third Wave Technologies,.... 68 President, Equity Resources, Inc.
- ----------------------- (1) Member of the compensation committee (2) Member of the audit committee (3) Member of the nominating and governance committee There are no family relationships among any(4) Member of the directors or executive officers of the Company.innovation and technology committee NOMINEES FOR ELECTION AT THE ANNUAL MEETING FOR TERMS ENDING IN 2006 John Neis has served as one of our directors since August 1994. Mr. Neis is Senior Partner of Venture Investors Management LLC, a firm that is the manager and general partner of Madison, Wisconsin-based venture capital management funds. He also serves on the Advisory Board of the Weinert Applied Ventures Program at the University of Wisconsin. Mr. Neis received a B.S. in finance from the University of Utah and an M.S. in business from the University of Wisconsin, and is a Chartered Financial Analyst.2009 Gordon F. Brunner has served as one of our directorsa director since January 2003. Mr. Brunner is currently a partner with Living Longer Proactive Health and was senior vice president, chief technology officer, head of worldwide research and development, andserved as Chief Technology Officer as well as a member of the board of directors of the Procter & Gamble Co.Company, until his retirement after 40 years of service. He has more than 40 years'extensive experience leveraging innovative technology platforms to the pharmaceutical, over-the-counter and consumer markets. He earnedreceived a B.S. degree in biochemical engineering from the University of Wisconsin-Madison and an M.B.A. degree from Xavier University. 3 Sam Eletr, Ph.D.Mr. Brunner is a partner in the Cincinnati Living Longer ProActive Health Center and serves as a director of one other public company, Scotts Miracle-Gro Corporation, as well as privately-held Iams Imaging and Beverage Holdings, LLC. He also serves on the boards for Christ Hospital (Cincinnati, Ohio), the Wisconsin Alumni Research Foundation and Xavier University. Lawrence Murphy was appointed to the Third Wave board of directors in January 2006. Mr. Murphy, an independent business consultant, brings to Third Wave's board more than 30 years of business experience in strategic partnerships, mergers and acquisitions, operations, finance, law and administration. He has served as one of our directors since June 2002. Dr. Eletr co-founded Applied Biosystems,the lead business advisor on significant transactions for his clients, including Jabil Circuit Inc. and, a publicly-held (NYSE) global electronics manufacturing service company with more than $7 billion in revenue. Mr. Murphy served as its Chairmanexecutive vice president and Chief Executive Officer. Prior to founding Applied Biosytems, Dr. Eletr managed the analytical and medical instruments group at Hewlett-Packard Co.'s corporate research laboratories. Dr. Eletr most recently co-founded and served as chairman and chief executive officersecretary of Lynx TherapeuticsCore Industries, Inc., a publicly traded genomics company.publicly-held (NYSE) diversified manufacturer, from 1981 until its sale in 1997. He earned an M.A.was a practicing attorney and certified public accountant before joining Core Industries. He received a B.S. degree in physics and a Ph.D. in biophysical chemistry, both ataccounting from the University of California-Berkeley.Detroit Mercy and a J.D., cum laude, from Wayne State University Law School. Mr. Murphy serves as a director of one other public company, Jabil Circuit, Inc. THE COMPANY'S BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE "FOR" THE NOMINEES SET FORTH ABOVE.NOMINEES. DIRECTORS WHOSE TERMS EXTEND BEYOND THE ANNUAL MEETING Lance Fors, Ph.D., our founder and ChairmanJames Connelly was appointed to the Third Wave board of directors in July 2005. Mr. Connelly is a partner in the Foley & Lardner law firm, where he served as founding chairman of the Board,health law practice. He brings to Third Wave more than 25 years of experience providing strategic business and legal advice to large health care networks, clinics and laboratories. He also has advised a number of emerging biotechnology and life sciences companies. Mr. Connelly earned his bachelor's degree from Marquette University and his law degree from the Georgetown University Law Center. He has served as a director and chairman of the board of numerous privately-held businesses and currently serves on the board of trustees of Ripon College. 3 Kevin Conroy has served as our President and Chief Executive Officer and as one of our directors since our inceptionDecember 2005. Mr. Conroy joined Third Wave as Vice President of Legal Affairs in 1993. Dr. Fors receivedJuly 2004 and served as General Counsel from October 2004 to December 2005. Prior to joining Third Wave, Mr. Conroy worked for GE Healthcare, where he oversaw the development and management of its information technologies group intellectual property portfolio, and developed and executed litigation, licensing, and corporate product acquisition legal strategies. Before joining GE, Mr. Conroy was an intellectual property litigator at two Chicago law firms, McDermott Will & Emery, and Pattishall, McAuliffe, Newbury, Hilliard and Geraldson, where he was a partner. He earned his Ph.D.B.S. in molecular biologyelectrical engineering at Michigan State University and his J.D. from the California InstituteUniversity of TechnologyMichigan. Lionel Sterling was appointed to the Third Wave board of directors in 1990. Dr. ForsAugust 2004. Mr. Sterling is president of Equity Resources, Inc., a private investment firm. He previously co-founded and served as managing partner of the private investment firm Whitehead/Sterling. Mr. Sterling serves on a number of corporate and philanthropic boards. He most recently served on the Board of I- STAT Corporation. He also has over twenty yearsserved as chairman of researchthe Board of Directors of Rayovac Corporation, Executive Vice President and development experienceDirector of United Brands Company, and is the inventor on 19 issuedSector Executive and pending patents in the areaChief Financial Officer of DNAAmerican Can Company. He also held various investment and RNA sequence analysis.financial positions at Donaldson, Lufkin & Jenrette Inc. and ITT Corporation. Mr. Sterling holds an M.B.A. from New York University. David A. Thompson, Chairman and Lead Independent Director, has served as one of our directors since August 1997.1997 and as Chairman and Lead Independent Director since 2005. Mr. Thompson retired from Abbott Laboratories in 1995, where he worked for overmore than 30 years. He held several corporate officer positions with Abbott Laboratories, including: Senior Vice President & President Diagnostic Division 1983-1995, Vice President Human Resources 1982-1983, Vice President Corporate Materials Management 1981-1982 and Vice President Operations 1974-1981. Mr. Thompson currently serves on the board of directors of St. Jude Medical Inc., a medical device company. Kenneth R. McGuire has served as one of our directors since October 1998. In 1986, Mr. McGuire founded the first of the Burbank Group of Companies, manufacturers of commercial aircraft noise suppression equipment. He has served as Chief Executive Officer of the member companies of the Burbank Group since their respective inceptions. Mr. McGuire receivedcompany and Fovi Optics, Inc, a B.S. from the United States Naval Academy and a J.D. from Columbia University. Tom Daniel has served as one of our directors since October 1999. He is General Partner with Schroder Ventures Life Sciences, a venture capital investment firm, where he has focused on life science investments in the United States and Europe since 1998. From 1995 to 1998, Mr. Daniel was an associate with Domain Associates, a United States venture capital firm focused on the life sciences. Before Domain, Mr. Daniel worked for Charles River Ventures, a United States venture capital firm focused on biotechnology investments. Mr. Daniel is a director of Oxagen and Solexa and is responsible for investments in Cellzome, Sunesis and a number of other private and public companies. Mr. Daniel received an M.B.A. from Harvard Business School, was a member of a genetics research team at the University of North Carolina, Chapel Hill from 1983-1984, and has an M.A. in Biological Sciences from Oxford University. G. Steven Burrill has served as one of our directors since October 1998. Mr. Burrill is Chief Executive Officer of Burrill & Company, a Life Sciences Private Merchant Bank which he founded in 1994. Prior to founding Burrill & Company, Mr. Burrill was a partner of Ernst & Young from 1977 through 1993. Mr. Burrill is a director of DepoMed, Galapagos Genomics, and Targacept. He currently serves as Board Chairman for Paradigm Genetics and Pyxis Genomics. Mr. Burrill received a B.B.A. from the University of Wisconsin, Madison. Lloyd M. Smith, Ph.D. has served as one of our directors since our formation and also serves on our scientific advisory board. Dr. Smith is Kellett Professor of Chemistry and Director of the Genome Center at the University of Wisconsin, Madison. Dr. Smith was the primary inventor of automated DNA sequence analysis. Dr. Smith regularly consults and advises us in our research and development efforts. He is chair of the scientific advisory boards of ProCognia Ltd. and GenTel Corporation and a member of the scientific advisory board of Curagen Corporation. VOTE REQUIRED Directors are elected by a plurality of the votes cast. Shares represented by executed proxies will be voted, if authority to do so is not withheld, for the election of the three nominees. Votes withheld from any director will have no effect on the outcome. 4 privately held business. BOARD MEETINGS,OF DIRECTORS AND COMMITTEES AND DIRECTOR COMPENSATION The board of directors heldprovides oversight with respect to the Company's strategic direction and significant corporate policies. Of the seven directors, all but Mr. Conroy are "independent" as such term is defined in the listing standards of the Nasdaq Stock Market. The board of directors has four standing committees: a totalcompensation committee, an audit committee, a nominating and governance committee, and an innovation and technology committee. From time to time, the board has created various ad hoc committees for special purposes. The board of six meetingsdirectors met eight times during 20022005 and all directors attended at least 75% of the total number of meetings of the board and committees of the board on which the director served during 2002.2005. The board held a total of four executive sessions during 2005. The Company encourages but does not require its directors to attend the annual meeting of stockholders. One director attended the 2005 annual meeting of stockholders. Stockholders may contact our board of directors, hasan individual director, or a specified board committee or group, by writing to them at the following address: c/o Corporate Secretary Third Wave Technologies 502 S. Rosa Road Madison, WI 53719 The Corporate Secretary will have discretion to determine whether a communication is proper for submission to the intended recipient. Communications that raise personal grievances, are solicitations, do not relate to the Company or that are frivolous are presumptively inappropriate for delivery. For further detail on the procedures for contacting our board of directors, please visit the corporate governance section of our website www.twt.com. 4 COMPENSATION COMMITTEE Gordon Brunner, Lawrence Murphy, John Neis and David Thompson currently serve on the compensation committee. Each member of the compensation committee an audit committee and a nominating committee. From time to time,is "independent" as such term is defined in the board has created various ad hoc committees for special purposes. The compensation committee consistslisting standards of Messrs. Smith, Neis and Daniel.the Nasdaq Stock Market. The compensation committee makes recommendations to the board of directors regarding our employee benefit plans and the compensation of our officers. The compensation committee heldmet three times during 2005. The compensation committee operates under a total of four meetings during 2002.Compensation Committee Charter, which is available at the Company's website www.twt.com. AUDIT COMMITTEE The audit committee consistsrecommends to the board the appointment of Messrs.our independent auditors, directs the scope of the audit of our financial statements and other services provided by our independent auditors, reviews the accounting principles and procedures to be used for financial statements and reviews the results of the audit. The audit committee also is responsible for the pre- approval of all services provided by our independent auditors. James Connelly, Lawrence Murphy, John Neis Burrill and Daniel.Lionel Sterling currently serve on the audit committee. Each member of the audit committee is "independent" as such term is defined in the listing standards of the National AssociationNasdaq Stock Market. Mr. Sterling, Mr. Neis and Mr. Murphy are each considered an "audit committee financial expert" as such term is defined by the rules of the Securities Dealers.and Exchange Commission in Item 401(h)(1) of Regulation S-K. The audit committee makes recommendations tooperates under an Audit Committee Charter, which is available at the boardCompany's website www.twt.com and a copy of directors regarding the selection of independent auditors, reviews the scope of audit and other services by our independent auditors, reviews the accounting principles and auditing practices and procedures to be used for our financial statements and reviews the results of those audits.which is attached hereto as Annex A. Information regarding the functions performed by the audit committee and the number of meetings held during 20022005 is set forth in the "Report of the Audit Committee",Committee," included in this proxy statement. NOMINATING AND GOVERNANCE COMMITTEE The nominating committee consists of Messrs. Daniel, Neis, Smith and Thompson. The nominatinggovernance committee evaluates and recommends candidates for election or appointment to the board of directors. The nominating and governance committee held four meetings in 2002.has not established any specific minimum qualifications that any candidate for director must meet, but considers a wide array of factors, including the candidate's knowledge of our industry, the candidate's educational and professional experience as well the candidate's reputation. The nominating and governance committee met three times in 2005. The nominating and governance committee operates under a Nominating and Governance Committee Charter, which is available at the Company's website www.twt.com. Gordon Brunner, Lionel Sterling and David Thompson currently serve on the nominating and governance committee. Each member of the nominating and governance committee is "independent" as such term is defined in the listing standards of the Nasdaq Stock Market. The nominating and governance committee will consider director candidates recommended by shareholders.stockholders. Recommendations may be sent to John Comerford, Vice President, General Counsel andCorporate Secretary, 502 South Rosa Road, Madison, Wisconsin 53719. Any recommendation submitted by a stockholder must include the name and address of the stockholder, any arrangements between the stockholder and the candidate pursuant to which the candidate is being nominated, and any information that would be required under the rules of the Securities and Exchange Commission to be included in the proxy statement had the candidate been nominated by the board of directors. The nominating and governance committee will apply the same standards in considering candidates submitted by stockholders as it applies to other candidates. INNOVATION AND TECHNOLOGY COMMITTEE The innovation and technology committee assists the board in providing counsel to the Company's senior management on strategic management of basic technology, innovation, medical affairs, and regulatory issues including the portfolio of development projects, management and tracking systems for critical projects, technology development and acquisition plans, and technical personnel development. The committee also assists the board and the company in interfacing with appropriate advisory and thought leader interactions. 5 Gordon Brunner and James Connelly currently serve on the innovation and technology committee. The board of directors has determined that each member of the innovation and technology committee is "independent" as such term is defined in the listing standards of the Nasdaq Stock Market. COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION None of the members of the compensation committee is currently, or has ever been at any time since our formation, an officer or employee of the Company or any of its subsidiaries. No memberNone of the compensation committeeour executive officers serves as a member of the board of directors or compensation committee of any entity that itself has one ofor more officers serving as a member of our board of directors or compensation committee. None of the members of Third Wave's compensation committee serves as an executive officer of any entity that has one or more of our officers serving as a member the board of directors or compensation committee. DIRECTOR COMPENSATION Upon initial election, our non-employee directors receive a stock option grant of 30,00045,000 options. The exercise price of these options is determined byequal to the fair market valueclosing price of the companyCompany's common stock onfrom the date of grant.last business day prior to the grant date. Following the third year ofafter initial election, our non-employeenon- employee directors receive an annual grant of 10,00015,000 options. OptionsOne-third of the initial options vest at 25% per yearon each of the first three anniversary dates of the grant and the annual option grants vest in full on the first anniversary date of the option grant and acceleratedate; provided, the options vest in full upon a change of control consistent with the terms outlined in the company's stock option grant agreements.control. Our non-employee directors receive an annual retainer of $12,000,$40,000, a board meeting fee of $1,500 for regularly scheduled board meetings physically attended and a board$500 for each meeting attended by teleconference. Committee chairs receive an additional annual retainer of $7,500 and directors who hold committee meeting participation feepositions receive an additional annual retainer of $500$5,000 for each committee participation. Our chairman and lead independent director, Mr. Thompson, receives an additional $15,000 per meeting.year for serving in such position. Our directors are reimbursed for allreasonable director-related expenses incurred as a result of providing service to the companyCompany or at the company'sCompany's request. PROPOSAL NO. 2 RATIFICATION OF APPOINTMENT OF AUDITORSINDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM The audit committee and the board of directors has based on the determination of the audit committee, appointed Ernst & YoungGrant Thornton LLP as the independent auditorsregistered public accounting firm of the Company for the current fiscal year ending December 31, 2003.2006. In May 2005 and after evaluating several independent accounting firms, the audit committee and the board of directors appointed Grant Thornton LLP as the Company's independent registered public accounting firm for the 2005 fiscal year. In connection with this action, on May 31, 2005, Third Wave dismissed Ernst & Young LLP as its independent registered public accounting firm for the 2005 fiscal year. During Third Wave's two most recent fiscal years, the opinion of Ernst & Young LLP did not contain an adverse opinion or disclaimer of opinion and was not qualified or modified as to uncertainty, audit scope, or accounting principles. The decision to change accounting firms was approved by Third Wave's audit committee and board of directors. During each of the two fiscal years ended December 31, 2003 and 2004, and in the subsequent interim period, there were no disagreements with Ernst & Young LLP on any matter of accounting principles or practices, financial statement disclosure, or auditing scope or procedure, which disagreements, if not resolved to the satisfaction of Ernst & Young LLP, would have audited the Company's financial statements sincecaused it to make reference thereto in its inception. 5reports for those periods. 6 FEES PAID OR DUE TO ERNST & YOUNG LLP Audit Fees. The aggregatetable below shows the total fees for professional services renderedbilled by Ernst & Young LLP for its services in connection with their 2002 annual2005 and 2004.
2005 2004 ------- -------- Audit Fees(1)........................................... $22,910 $488,800 Audit-Related Fees(2)................................... 9,100 1,500 Tax Fees(3)............................................. 12,133 32,895 All Other Fees.......................................... 0 0 ------- -------- Total................................................... $44,143 $523,195 ======= ========
- -------- (1) 2004 Audit Fees consist of the aggregate fees billed for professional services rendered for the audit of the Company's 2004 financial statements and reviews of the financial statements included in ourthe Company's Quarterly Reports on Form 10-Q for 2002 were approximately $261,500. Financial Information Systems Designsuch year and Implementation Fees. The Company did not engageservices that are normally provided by the independent public accounting firm in connection with statutory and regulatory filings or engagements. These fees included fees billed for review and evaluation of the Company's internal control over financial reporting and attest services relating thereto. 2005 Audit fees consist of fees billed for review of the financial statements included in the Company's Quarterly Report on Form 10-Q for the first quarter of 2005 and for review of the Company's Form 10-K for 2005 required to obtain Ernst & Young LLPLLP's consent to undertake any financial information systems design and implementation work during 2002. All Other Fees. Theinclude its 2004 audit report in such filing. (2) Audit-related fees consisted of the aggregate fees billed for assurance and related services that are reasonably related to the performance of the audit or review of the Company's consolidated financial statements and are not reported under "Audit Fees." (3) Tax fees principally included review of and consultation regarding the Company's federal, state and foreign tax returns and tax planning. FEES PAID OR DUE TO GRANT THORNTON LLP The table below shows the total fees billed by Grant Thornton LLP for its services in 2005. Grant Thornton did not provide any services in 2004.
2005 -------- Audit Fees(1).................................................. $194,225 Audit-Related Fees(2).......................................... 13,896 Tax Fees(3).................................................... 8,256 All Other Fees................................................. -- -------- Total.......................................................... $216,377 ========
- -------- (1) Audit Fees consist of the aggregate fees billed for professional services rendered for the audit of the Company's annual financial statements and reviews of the financial statements included in the Company's Quarterly Reports on Form 10-Q and services that are normally provided by the independent public accounting firm in connection with statutory and regulatory filings or engagements. These fees included fees billed for review and evaluation of the Company's internal control over financial reporting and attest services relating thereto. (2) Audit-related fees consisted of the aggregate fees billed for assurance and related services that are reasonably related to the performance of the audit or review of the Company's consolidated financial statements and are not reported under "Audit Fees." (3) Tax fees principally included review of and consultation regarding the Company's federal, state and foreign tax returns and tax planning. The audit committee has considered whether the provision of the non-audit services described above is compatible with maintaining the independence of Grant Thornton LLP and determined that such services are compatible with maintaining such independence. 7 The audit committee has adopted a policy that requires pre-approval by the audit committee of all services to be provided by the Company's independent registered public accounting firm. The audit committee has approved the provision of audit services by Grant Thornton LLP for fiscal year 2006 in accordance with that policy. All other services renderedto be provided by Ernst & Young LLP in 2002 was approximately $51,020, consistingthe Company's independent auditor must be specifically pre-approved by the audit committee or a designated member of the audit related services of approximately $15,145 and non-audit services of approximately $35,875. Audit related services generally include fees for accounting consultations and registration statements.committee. Representatives of Ernst & YoungGrant Thornton LLP are expected to be present at the annual meeting with the opportunity to make a statement if they desire to do so and are expected to be available to respond to appropriate questions. If shareholdersstockholders fail to ratify the selection of Grant Thornton LLP as the independent registered public accounting firm for 2006, the audit committee and the board of directors will reconsider whether or not to retain that firm. Even if the selection is ratified, the audit committee and the board may, in their discretion, may direct the appointment of a different independent auditorsregistered public accounting firm at any time during the year. THE COMPANY'S BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE "FOR" THE RATIFICATION OF THE APPOINTMENT OF ERNST & YOUNGGRANT THORNTON LLP AS THE COMPANY'S INDEPENDENT AUDITORSREGISTERED PUBLIC ACCOUNTING FIRM FOR THE FISCAL YEAR ENDING DECEMBER 31, 2003. VOTE REQUIRED The ratification of the appointment of Ernst & Young LLP requires the affirmative vote of a majority of the shares of common stock represented at the annual meeting and entitled to vote thereon. 6 2006. EXECUTIVE COMPENSATION SUMMARY COMPENSATION TABLE The following table sets forth the compensation paid by us during 2000, 20012005, 2004 and 20022003 to our chief executive officer, and our next four most highly compensated other executive officers who received salary compensation of more than $100,000 during 20022005, any person who served as chief executive officer during 2005 and any other executive officer who would be included by virtue of the foregoing criteria but for the fact that individual was not serving as an executive officer at the end of the 2005 fiscal year (the "Named Executive Officers"). SUMMARY COMPENSATION TABLE
LONG-TERM COMPENSATION --------------- ANNUAL COMPENSATION SECURITIES ----------------------------------------------------------- UNDERLYING ALL OTHER NAME PRINCIPAL POSITION(S) YEAR SALARY($) BONUS($)(1) OPTIONS/SARS(#) COMPENSATION($) - ---- --------------------- ---- --------- --------------------- --------------- --------------- Dr. Lance Fors.........Kevin T. Conroy(2)...... President, Chief 2002 $398,239 $150,000 291,000 $ 2,826(2)2005 $254,248 -- 315,000 $36,702(3) Executive Officer 2001 $384,790 $0 141,480 Chairman,2004 $139,662 $ 90,000 295,000 $13,842(4) and Director 2000 $317,513 $166,600 693,600 John J. Puisis(1)......Maneesh Arora(5)........ Chief Financial 2005 $312,673 -- 60,000 $20,263(6) Officer 2004 $278,134 $ 75,000 68,333 $28,887(7) 2003 $206,739 $110,000 350,000 $26,819(8) Ivan Trifunovich........ Senior Vice 2002 $253,380 $150,000 145,000 $20,705(2) President 2005 $297,319 -- 75,000 $ 6,300(9) 2004 $269,972 $106,000 32,000 $ 6,500(9) 2003 $263,693 $ 85,750 -- $ 6,000(9) Lander Brown(10)........ Former, Vice 2005 $241,091 $155,927(11) 65,000 $23,766(12) President Human 2004 $ 18,667 $ 69,390 200,000 -- Resources & Administration James Herrmann(13)...... Former Vice 2005 $218,623 $100,000(14) 165,000 $48,229(15) President, Finance 2004 $ 67,604 $ 45,000 175,000 -- John Puisis............. Former President, 2005 $522,315 -- 300,000 $35,334(16) Chief 2001 $ 65,587 $2,111,864 275,000 $ 4,924(2) FinancialExecutive 2004 $440,305 $286,000 29,333 $20,987(17) Officer Chief Operating Officer Dr. Bruce Neri......... Senior Vice 2002 $247,549 $75,000 145,000 President, Research 2001 $221,987 $0 59,400 & Development 2000 $193,734 $68,750 62,400 Ivan Trifunovich(3).... Senior Vice 2002 $260,713 $0 100,000 President & 2001 $ 0 $0 210,000 General Manager, Genomics Business Unit John Comerford(4)...... Vice President, 2002 $209,879 $15,000 140,000 General Counsel & 2001 $200,461 0 81,000 Secretary 2000 $ 53,539 $21,678 39,600and Director 2003 $349,798 $200,000 480,000 $24,246(18)
- ----------------------- (1) Reflects total bonus earned in applicable year. (2) Mr. PuisisConroy joined usthe Company in September 2001. (2) ConsistsJuly 2004. 8 (3) Represents payment of relocation$30,402 for commuting expenses paid by us. (3)and a Company matching contribution to a 401(k) plan of $6,300. (4) Represents payment of $12,026 for commuting expenses a Company matching contribution to a 401(k) plan of $1,816. (5) Mr. TrifunovichArora joined usthe Company in January 2003. (6) Represents payment of $13,947 for commuting expenses and a Company matching contribution to a 401(k) plan of $6,316. (7) Represents payment of $22,387 for commuting expenses and a Company matching contribution to a 401(k) plan of $6,500. (8) Represents payment of $21,437 for commuting expenses and a Company matching contribution to a 401(k) plan of $5,382. (9) Represents a Company matching contribution to a 401(k) plan. (10) Mr. Brown joined the Company in December 2001. (4)2004. (11) Includes a signing bonus of $77,527. (12) Represents payment of $19,925 for commuting expenses and a Company matching contribution to a 401(k) plan of $3,841. (13) Mr. ComerfordHerrmann joined usthe company in September 2000.October 2004. (14) Represents a signing bonus. (15) Represents payment of $41,929 for commuting expenses and a Company matching contribution to a 401(k) plan of $6,300. (16) Represents payment of $29,034 for commuting expenses and a Company matching contribution to a 401(k) plan of $6,300. (17) Represents payment of $14,487 for commuting expenses and a Company matching contribution to a 401(k) plan of $6,500. (18) Represents payment of $18,246 for commuting expenses and a Company matching contribution to a 401(k) plan of $6,000. OPTION GRANTS IN 20022005 The following table sets forth information relating to stock options granted during 20022005 to the Named Executive Officers. In accordance with the rules of the Securities and Exchange Commission, also shown below is the potential realizable value overduring the term of the option (the period from the grant date to the expiration date) based on assumed rates of stock appreciation of 5% and 10%, compounded annually. These amounts are mandated by the Securities and Exchange Commission and do not represent our estimate of 7 future stock price. Actual gains, if any, on stock option exercises will depend on the future performance of our common stock.
POTENTIAL REALIZABLE INDIVIDUAL GRANTS -----------------------------------------------------VALUE AT ASSUMED -------------------------------------------------- ANNUAL RATES OF PERCENT OF POTENTIAL REALIZABLE VALUE ATSTOCK NUMBER OF TOTAL ASSUMED ANNUAL RATES OFPRICE APPRECIATION SECURITIES OPTIONS STOCK PRICE APPRECIATION FOR UNDERLYING GRANTED TO EXERCISE OPTION TERM OPTIONS EMPLOYEES IN PRICE PER EXPIRATION ----------------------------------------------- NAME GRANTED(#)(1) 2002(2)2005(2) SHARE($) DATE 5%($) 10%($) - ---- ------------- ------------ --------- ---------- ------------- -------------------- --------- Dr. Lance Fors....... 291,000 12.61 2.13 6/Kevin T. Conroy............ 65,000 2.6% 4.23 04/29/2015 172,915 483,199 250,000 9.9% 2.82 12/2012 389,808 987,84929/2015 443,371 1,123,588 Maneesh Arora.............. 60,000 2.4% 4.23 04/29/2015 159,613 404,492 Ivan Trifunovich........... 75,000 3.0% 4.23 04/29/2015 199,517 505,615 Lander Brown............... 65,000 2.6% 4.23 04/29/2015 172,915 483,199 James J. Herrmann.......... 65,000 2.6% 4.23 04/29/2015 172,915 483,199 100,000 4.0% 4.65 08/01/2015 292,436 741,090 John J. Puisis....... 145,000 6.28 2.13 6/12/2012 194,234 492,227 Dr. Bruce Neri....... 145,000 6.28 2.13 6/12/2012 194,234 492,227 Ivan Trifunovich..... 100,000 4.33 2.13 6/12/2012 133,955 339,467 John Comerford....... 140,000 6.07 2.13 6/12/2012 187,536 475,254Puisis............. 300,000 11.9% 4.23 04/29/2015 798,067 2,022,459
- ----------------------- (1) For each of the Named Executive Officers, 25% of the options vest on each of the first four anniversaries of the grant date.date provided the options vest in full upon a change of control. 9 (2) WeDuring 2005, we granted options to purchase a total of 2,307,9502,521,790 shares of common stock during 2002.stock. AGGREGATE OPTION EXERCISES IN 20022005 AND FISCAL YEAR-END OPTION VALUES The following table sets forth information for the Named Executive Officers relating to option exercises in 20022005 and the number and value of securities underlying exercisable and unexercisable options held at December 31, 2002:2005:
NUMBER OF SECURITIES UNDERLYING UNEXERCISED VALUE OF UNEXERCISED OPTIONS AT IN-THE-MONEY OPTIONS AT SHARES DECEMBER 31, 200231,2005 DECEMBER 31, 2002(1)2005($)(1) ACQUIRED ON VALUE --------------------------- ----------------------------------------------------- -------------------------- NAME EXERCISE(#) REALIZED($) EXERCISABLE UNEXERCISABLE EXERCISABLE UNEXERCISABLE - ---- ----------- ------------------------- ----------- ------------- ----------- ------------- Dr. Lance Fors.......Kevin T. Conroy.......... 0 0 601,770 674,310 99,792 119,310 John Puisis..........130,000 480,000 0 40,000 Maneesh Arora............ 0 0 275,000 145,000 59,450 Dr. Bruce Neri.......192,083 286,250 29,750 29,750 Ivan Trifunovich......... 0 0 181,650 214,750 184,800 59,450 Ivan Trifunovich.....293,000 124,000 63,750 21,250 Lander Brown............. 0 0 52,500 257,500 41,000 John Comerford.......0 65,000 0 0 48,750 211,850 57,400James Herrmann........... 0 0 175,000 165,000 0 0 John J. Puisis........... 0 0 1,229,333 0 204,450 0
- ----------------------- (1) Value of unexercised in-the-money options are based on a value of $2.54$2.98 per share, the fair market value of our common stock on December 31, 2002.2005. Amounts reflected are based on the value of $2.54$2.98 per share, minus the per share exercise price, multiplied by the number of shares underlying the option. LONG-TERM INCENTIVE PLAN -- AWARDS IN FISCAL YEAR 2005
ESTIMATED FUTURE PAYOUTS UNDER NON-STOCK PRICE-BASED PLANS(1) PERFORMANCE -------------------------------------- NAME PERIOD THRESHOLD ($) TARGET ($) MAXIMUM ($) - ---- ----------- ------------- ---------- ----------- Kevin T. Conroy........................... 2005-2007 -- 750,000 1,500,000 Maneesh Arora............................. 2005-2007 -- 464,000 928,000 Ivan Trifunovich.......................... 2005-2007 -- 371,000 742,000 Lander Brown(2)........................... 2005-2007 -- -- -- James J. Hermann(2)....................... 2005-2007 -- -- -- John J. Puisis(2)......................... 2005-2007 -- -- --
- -------- (1) The target payout amount for each officer equals four times the highest annual incentive award target established for the participant during the performance period. As a result, the target payout amounts may increase in the future based upon the annual incentive award targets established for 2006 and 2007. The maximum payout is equal to two times the target payout amount. (2) Although awards were made to Mr. Brown, Mr. Herrmann and Mr. Puisis in 2005, such awards were forfeited in connection with the termination of their employment with Third Wave. During 2005, the board granted contingent long term performance awards under the Company's Long Term Incentive Plan No. 2 to select employees covering the 2005-2007 period to provide a continued emphasis on specified financial performance goals which the board considers to be important contributors to long-term stockholder value. The cash awards will be payable only if the Company achieves specified goals over the performance period for the following three measurements: the Company's total shareholder return ranking as compared to its peer group, the Company's stock price growth and the growth in the Company's clinical molecular diagnostics revenue. Twenty-five percent of an award vests on the day it is earned (the last day of the performance period), fifty percent on the first anniversary of such date and the remaining twenty-five percent on the second anniversary of such date, provided the participant continues to be employed by the Company through the applicable vesting date. If a participant retires at or after his or her normal retirement age, becomes disabled, or dies while employed by the 10 Company, the participant's award fully vests at the end of the performance period or at the time such event occurs, whichever is later. Unless otherwise specified in an employment or other agreement between the participant and Third Wave, if a participant's employment with Third Wave terminates for any other reason, any unvested portion of any award is forfeited. In the event of a change of control of the Company during the performance period, all outstanding awards would be deemed earned and become vested as described below under "Employment Contracts and Change-in-Control Arrangements." The Company also has a Long Term Incentive Plan No. 1 covering the 2004- 2006 period and a Long Term Incentive Plan No. 3 covering the 2006-2008 period. The terms of all of the Company's long term incentive plans are the same other than the performance targets and performance periods. EMPLOYMENT AGREEMENTS WITH EXECUTIVE OFFICERS We haveCONTRACTS AND CHANGE-IN-CONTROL ARRANGEMENTS Mr. Conroy and the Company entered into an amended employment agreement with Mr. Puisis thatin December of 2005 which provides for an initial base salary of $225,000$375,000 and a target bonus opportunity equal to 50% of Mr. Conroy's base salary, with the exact amount to be determined by the Compensation Committee. Under his agreement, Mr. Conroy participates in our long term incentive plans, participates in the benefits programs generally provided to our similarly situated employees, receives four weeks of paid vacation each calendar year, is entitled to reimbursement for up to $60,000 in relocation expenses and reasonable and necessary out-of-pocket business expenses and was granted 250,000 incentive stock options with an exercise price of $2.82 and a term of 10 years. Under his agreement, Mr. Conroy would, upon termination without "cause" or resignation for "good reason," receive (1) severance pay for a period of 18 months at his then current base salary; provided that if termination occurs within twelve months before or after a change in control severance would be payable for 24 months, (2) any accrued but unpaid base salary and annual incentive bonus as of no less than 22.5%the termination date, (3) the pro rata portion of base salary. The agreementtarget annual incentive bonus, provided that an annual incentive bonus is paid to other senior executives of the Company at the end of the applicable year, (4) if termination occurs within one year following a change in control, the pro rata portion of the target annual incentive bonus, regardless of whether or not an annual incentive bonus is paid to other senior executives of the Company, (5) a pro rata portion of any long term incentive plan awards that are earned based on the satisfaction of performance targets set forth in such plans and without the requirement of continued employment, and (6) accelerated vesting of fifty percent (50%) of then unvested stock options. Any payments due Mr. Conroy as a result of a change in control would be grossed-up so that the net amount retained by him, after deduction of any parachute payment excise taxes, would equal the amounts payable as described above. Additionally, in the event a change in control occurs within 12 months after Mr. Conroy's termination without "cause" or resignation for an initial option grant"good reason," any long term incentive plan awards made to Mr. Puisis and forConroy would become payable as described below notwithstanding such termination of employment as if Mr. Conroy were employed as of the one-time sign-on bonus to Mr. Puisis (the "Sign-on Bonus") listed under "Summary Compensation Table" to partially compensate Mr. Puisis for certain moneys losteffective date of the change in control. Further, upon Mr. Puisis beginning employment with us. Mr. Puisis' employment may be terminated by either us or Mr. Puisis at any time, except that (i) if we terminate Mr. Puisis for "cause" (as defined in the employment agreement) or Mr. Puisis voluntarily terminates his employmenttermination other than for "good reason" (as defined in the employment agreement) after the first twelve months but within the first twenty-four months, Mr. Puisis must repay to us $700,000 of the Sign-on Bonus and (ii) if we terminate Mr. Puisis other thantermination for "cause" or resignation without "good reason," all vested options would become open for exercise until the earlier of (1) two years from termination and (2) expiration notwithstanding such termination of employment. The agreement also prohibits Mr. Puisis voluntarily terminatesConroy from engaging in certain activities involving competition with us for an 18-month period following termination of his employment with the Company. In May 2005, the Company entered in to an employment agreement with Maneesh Arora under which Mr. Arora is being paid a salary of $265,000 and has a target annual incentive bonus opportunity equal to 40% of such base salary. Under his agreement, Mr. Arora would, upon termination without "cause" or resignation for "good reason", Mr. Puisis wouldreason," receive (1) a lump sum severance paymentamount equal to one year's base salary, and(2) if termination occurs within one year following a pro-ratedchange in control, the pro rata portion of histhe target annual incentive bonus, (3) twelve months of health insurance premiums, (4) $10,000 of outplacement consulting fees and continued coverage(5) earned but unpaid bonuses. Additionally, in the event a change in control occurs within 12 months after Mr. Arora's termination without "cause" or resignation for one year under our health and other welfare benefit plans. The"good reason," any long term incentive plan awards made to Mr. Arora would become payable as described below notwithstanding such termination of employment agreement withas if Mr. Puisis defines "good reason" to include (i) Dr. Fors voluntarily ceasing to be the CEO or ChairmanArora were employed as of the 8 boardeffective date of directors within eighteen months of the beginning of Mr. Puisis' employment and (ii) a resignation by Mr. Puisis following a "change of control" (as defined in the employment agreement), but not earlier than six months after the change in control. The agreement also prohibits Mr. Arora from engaging in certain activities involving competition with us for an 12-month period following termination of his employment with the Company. The Company's long term incentive plans provide for deemed satisfaction of performance goals and accelerated vesting in the event of a change of control of the Company during a performance period as follows. 11 With respect to Long-Term Incentive Plan No. 1, in connection with any change in control all performance goals would be deemed satisfied and all Named Executive Officers would be deemed to have immediately earned the maximum payout due for all long term incentive awards granted to the Named Executive Officer. With respect to Long-Term Incentive Plan No. 2 and Long-Term Incentive Plan No. 3, in connection with change in control, all performance goals would be deemed satisfied and all Named Executive Officers would be deemed to have immediately earned the maximum payout due for all long term incentive awards granted to the Named Executive Officer, unless the change in control is an acquisition or merger for less than $200 million in total value, in which case all performance goals would be deemed satisfied only to the extent the performance targets are satisfied as of the date of the change in control after taking into account on a straight-line basis the shortened time period within which to achieve such performance goals. Mr. Puisis, our former President and Chief Executive Officer, resigned on December 14, 2005. In connection with Mr. Puisis' resignation, he and the Company entered into a severance agreement under which he is entitled to the following severance benefits: (1) an amount equal to $880,000 in cash, $220,000 of which was paid up front and the remainder of which is payable in 18 monthly installments, (2) $33,572 in cash payable in 12 monthly installments and (3) up to $15,000 in outplacement consulting services. In addition, under his severance agreement all previously granted, but unvested, stock options became immediately vested and open for exercise until expiration notwithstanding termination of employment. Mr. Herrmann, our former Vice President of Finance, resigned on March 16, 2006. In connection with Mr. Herrmann's resignation, he and the Company entered into a severance agreement under which he is entitled to the following severance benefits: (1) severance pay at his current salary level of $225,000 through December 31, 2006, (2) a supplemental transition payment of $25,000, less applicable taxes, payable on January 15, 2007 and (3) in exchange for the return of his vested option to purchase 175,000 shares of our common stock, an option grant on March 16, 2006 to purchase 43,750 shares of our common stock. EQUITY COMPENSATION PLAN INFORMATION The following table summarizes the number of outstanding options granted to employees, directors and directors,consultants, as well as the number of securities remaining available for future issuance, under our compensation plans as of December 31, 2002.2005.
NUMBER OF SECURITIES REMAINING AVAILABLE FOR FUTURE ISSUANCE NUMBER OF SECURITIES WEIGHTED AVERAGE UNDER EQUITY TO BE ISSUED UPON EXERCISE PRICE COMPENSATION PLANS EXERCISE OF OUT- OF OUTSTANDING (EXCLUDING SECURITIES STANDING OPTIONS, OPTION WARRANTS REFLECTED IN THE PLAN CATEGORY WARRANTS AND RIGHTS AND RIGHTS FIRST COLUMN) - ------------- -------------------- --------------------------------- --------------------- Equity compensation plans approved by security holders......................... 6,140,859 $5.35 2,801,587 Equity compensation plans not approved by security holders.........................EQUITY COMPENSATION PLANS APPROVED BY SECURITY HOLDERS Incentive Stock Plans............... 9,101,298 $ 4.34 1,914,539 Employee Stock Purchase Plan........ Not Applicable(1) Not Applicable(1) 431,114 Total............................... 9,101,298 $ 4.34 2,345,653 EQUITY COMPENSATION PLANS NOT APPROVED BY SECURITY HOLDERS None................................ 0 0 0 Total...................................... 6,140,859 $5.35 2,801,587---------------- ----------------- --------- NET TOTAL............................. 9,101,248 $ 4.34 2,345,653 ================ ================= ========= ===== ==========
- -------- (1) The Company maintains an Employee Stock Purchase Plan that permits employees to have payroll deductions made to purchase shares of Common Stock during specified purchase periods. The purchase price is the lower of 85% of (1) the fair market value per share of Common Stock on the first business day of the purchase period and (2) the fair market value per share of Common Stock on the last business day of the purchase period. 12 Consequently, the price at which shares will be purchased for the purchase period currently in effect and future purchase periods is not known. BOARD COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION The following report is provided to shareholdersstockholders by the compensation committee of the board of directors: The compensation committee of the board of directors, which is composed of three non-employee directors, is responsible for the administration ofadministers the Company's compensation programs. These programs include base salary for executive officers and both annual and long-termlong term incentive compensation programs. The Company's compensation programs are designed to provide a competitive level of total compensation and include incentive and equity ownership opportunities linked to the Company's performance and shareholderstockholder return. Compensation Philosophy. The Company's overall executive compensation philosophy is based on a series of guiding principles derived from the Company's values, business strategy and management requirements. These principles are summarized as follows: - Provideprovide competitive levels of total compensation whichthat will enable the Company to attract and retain the best possible executive talent; - Motivatemotivate executives to achieve optimum performance for the Company; - Alignalign the financial interest of executives and shareholdersstockholders through equity-based plans; and - Provideprovide a total compensation program that recognizes individual contributions as well as overall business results. Compensation Program. The compensation committee is responsible for reviewingreviews and recommendingrecommends to the board the compensation and benefits of all officers of the Company and establishes and reviews general policies relating to compensation and benefits of employees of the Company. The compensation committee is also responsible for the administration ofadministers the Company's 2000 Stock Plan.Plan and its long term incentive plans. There are two major components to the Company's executive compensation: - base salary and potential annual cash bonus, as well asand - potential long-termlong term compensation in the form of stock options.options and long term incentive plans. The compensation committee considers the total current and potential long-termlong term compensation of each executive officer in establishing each element of compensation. 1. Base Salary. In setting compensation levels for executive officers, the compensation committee reviews competitive information to compensation levels for comparable positions at biotechnology and 9 high technology companies. In addition, the compensation committee may, from time to time, hire compensation and benefit consultants to assist in developing and reviewing overall salary strategies. Individual executive officer base compensation may vary based on time in position, assessment of individual performance, salary relative to internal and external fairness and the critical nature of the position relative to the success of the Company. 2.Annual Incentive Awards. The Company establishes both corporate and individual goals and performance measures consistent with factors necessary to achieve strategic business objectives. Annual incentive awards paid to Company employees, including the executive officers, are determined based on a combination of the achievement of the predetermined corporate and individual performance goals and measures. The annual incentive awards are designed to drive individual and Company performance to enhance stockholder value. Long-Term Incentives. The Company's 2000 Stock Plan provides for the issuance of stock options to officers and employees of the Company to purchase shares of the Company's common stock at an exercise price equal to the fair market value of such stock on the date of grant. Stock options are granted to the Company's executive officers and other employees both as a reward for past individual and corporate performance and as an incentive for future performance. The compensation committee believes that stock-based performance compensation arrangements are essential in aligning the interests of management andwith the shareholdersstockholders in enhancing the value of the Company's equity. 3.13 In January 2004, the Company established a long term incentive plan designed to encourage results-oriented actions on the part of executive officers and other key employees of the Company. A second long term incentive plan was established in February 2005 and a third long term incentive plan was established in February 2006. Each of the plans covers a three-year performance period. Plan awards will become payable if and to the extent the Company attains the performance goals set by the committee for the relevant performance period. The plans are intended to align closely the financial rewards for executive officers and key employees with the interests of stockholders and the achievement of specific performance objectives of the Company. The plans are administered by the compensation committee, which establishes the term of the plans, performance goals, target awards, performance measurement criteria and calculation of awards. The plans are also designed to reduce reliance on stock option grants as the sole source of long term incentive compensation. Benefits. The Company provides benefits to the Named Executive Officers that are generally available to all employees of the Company. The amount of executive level benefits and perquisites, as determined in accordance with the rules of the Securities and Exchange Commission relating to executive compensation, did not exceed 10% of total salary and bonus for the calendar year 20022005 for any executive officer. Chief Executive Officer Compensation. In connection with his promotion to President and Chief Executive Officer in December 2005, Mr. Conroy and the Company entered into an amended employment agreement which provides an initial base salary of $375,000 and a target bonus opportunity equal up to 50% of base salary. Under the agreement Mr. Conroy received 250,000 stock options, with an exercise price of $2.82 and a term of 10 years. In determining Mr. Conroy's compensation, the board considered Mr. Conroy's responsibilities and duties, value and contributions to the Company and compensation levels for chief executive officers of other companies of comparable size and complexity in the Company's industry. The total compensation of Mr. Conroy is consistent with the Company's overall executive compensation philosophy as described above. Section 162(m) of the Internal Revenue Code Limitations on Executive Compensation. Section 162(m) of the United States Internal Revenue Code may limit the Company's ability to deduct for United States federal income tax purposes compensation in excess of $1,000,000 paid to the Company's chief executive officer and its four other highest paid executive officers in any one fiscal year. No executive officer of the Company received any such compensation in excess of this limit during fiscal 2002. The total compensation of Dr. Fors, the Company's Chief Executive Officer, is consistent with the Company's overall executive compensation philosophy as described above, and the compensation of Dr. Fors was based on the factors described above.2005. It is the opinion of the compensation committee that the aforementioned compensation policies and structures provide the necessary discipline to properly align the Company's corporate economic performance and the interest of the Company's shareholdersstockholders with progressive, balanced and competitive executive total compensation practices in an equitable manner. The foregoing report shall not be "soliciting material" or to be "filed" with the Securities and Exchange Commission, nor shall such information be incorporated by reference into any future filing under this Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, except to the extent the Company specifically incorporates it by reference into such filing. Respectfully submitted, The compensation committee of the board of directors Lloyd Smith, Ph.D. Tom DanielGordon Brunner Lawrence Murphy John Neis David Thompson EXECUTIVE OFFICERS OF THE COMPANY The executive officers of the Company as of April 25, 2003 are set forth below: Lance Fors, Ph.D. (45), our founder and Chairman of the Board,Kevin Conroy, (40) has served as our President and Chief Executive Officer and as one of our directors since our inceptionDecember 2005. Mr. Conroy joined Third Wave as Vice President of Legal Affairs in 1993. Dr. Fors receivedJuly 2004 and served as General Counsel from October 2004 to December 2005. Prior to joining Third Wave, Mr. Conroy worked for GE Healthcare, where he oversaw the development and management of its information technologies group intellectual property portfolio, and developed and executed litigation, licensing, and corporate product acquisition legal strategies. Before joining GE, Mr. Conroy was an intellectual property litigator at two Chicago law firms, McDermott Will & Emery, and Pattishall, McAuliffe, Newbury, Hilliard and Geraldson, where he was a partner. 14 He earned his Ph.D.B.A. in molecular biologyelectrical engineering at Michigan State University and his J.D. from the California InstituteUniversity of Technology in 1990. Dr. Fors has over twenty years of 10 research and development experience and is the inventor on 19 issued and pending patents in the area of DNA and RNA sequence analysis. John J. Puisis (43)Michigan. Maneesh Arora, (37) has served as our Senior Vice President, Chief Financial Officer since September 2001. In January 2003,2006. Mr. Puisis was also assigned the title and duties of Chief Operating Officer. From 1996 until he joined the Company, Mr. Puisis held senior management positions at the Spencer Stuart and Egon Zehnder executive recruitment firms, specializing in recruiting for the biotechnology and pharmaceutical industries. From 1989 to 1996, Mr. Puisis held key financial executive positions at DEKALB Genetics and Kraft Foods. Prior to 1989, Mr. Puisis held various positions at several large public accounting firms. Mr. Puisis earned an M.B.A. from Northwestern University and a B.A. in accounting from Northern Illinois University. He is a certified public accountant. Bruce Neri, Ph.D. (56)Arora joined us in July 1996January 2003 as Vice PresidentDirector of Research and DevelopmentStrategy and was promoted to Vice President of Marketing and Strategy in October 2003. In March 2004, he took on the role of Senior Vice President of Research and Development in July 1997. From 1991 until joining us, Dr. Neri was Vice President of DNA probe development at Becton, Dickinson and Company.Commercial Operations. Prior to 1991, Dr. Neri directed Researchjoining Third Wave, Mr. Arora was Director of Corporate Strategy and DevelopmentNew Ventures for Ondeo Nalco, a $3-billion subsidiary of Suez, a global provider of industrial services. Previous to that, he spent nine years at Gene-Trak Systems, Angenics, Inc., Instrumentation LaboratoriesKraft Foods in a number of key roles of increasing responsibility in finance, marketing and Abbott Laboratories. Dr. Neri issales. Mr. Arora received his M.B.A. in management and strategy from the inventor on ten United States patents, with an additional 19 pending in the areaKellogg Graduate School of human in-vitro diagnostic products,Management and over 60 publications. Dr. Neri received ahis B.A. in chemistry from Cornell College and a Ph.D. in analytical chemistryeconomics from the University of Arizona.Chicago. Ivan D. Trifunovich, Ph.D. (39), (42) joined us as Senior Vice President and General Manager of our Genomics business unit in December 2001. From 1999 until joining us, Dr. Trifunovich was, successively,previously held successive positions as Vice President of e-Business and Vice President of Research Strategy and Operations at Pharmacia Corp. Prior to 1999,joining Pharmacia, Dr. Trifunovich was a Director of New Product Marketing at Johnson & Johnson, Inc. From 1992 to 1997,He began his career at Bristol- Meyers Squibb, Inc. as a bench scientist, where he held several positions of increasing responsibility. Dr. Trifunovich held various positions at Bristol-Meyers Squibb, Inc. Dr. Trifunovich earnedreceived his Ph.D. in organic chemistry at UCLA and hisan M.B.A. at the University of Pennsylvania's Wharton School of Business. He is the holder of ten10 U.S. patents. Cindy S. Ahn, (33) joined us in April 2006 as Vice President, Legal and General Counsel. Prior to joining Third Wave, Ms. Ahn was a partner in the intellectual property litigation department at the Chicago office of Kirkland & Ellis LLP. Ms. Ahn also practiced intellectual property law at Finnegan, Henderson, Farabow, Garrett & Dunner in Washington, D.C. Ms. Ahn earned her B.S. in biology at University of Illinois at Urbana-Champaign and her J.D. at American University, Washington College of Law. John ComerfordBellano, (37) joined us in February 2005 as Regional Vice President of Sales from Roche Diagnostics. He was promoted to Vice President Sales in January 2006. Mr. Bellano joined Roche in early 2000, where he became one of four regional business managers for its molecular business in the United States. As a regional business manager, he hired and developed a sales team of 11 representatives with revenues of more than $50 million. His sales organization regularly exceeded its goals. Mr. Bellano has also managed multi-million dollar territories for Abbott Laboratories and Sanofi Diagnostics Pasteur, where he was responsible for infectious disease products in the northeastern United States. Jorge A. Garces, (34) was appointed Vice President of Product and Platform Development in April 2006. He joined Third Wave as Executive Director of Clinical Development in October 2005. Prior to joining Third Wave, Dr. Garces served as Director of Molecular R&D at Genzyme Genetics, where he oversaw the technology and product development activities of laboratory staff in New York, Los Angeles, and Westborough, MA. Before joining Genzyme, Dr. Garces worked as an associate product manager and R&D scientist at Athena Diagnostics and served as a database curator for Proteome, Inc. He earned his B.A. in biology from Brooklyn College and his Ph.D. in Cell and Molecular Biology from the City University of New York. Dr. Garces completed his post-doctoral training at the University of Massachusetts Medical School. Greg Hamilton, (36) joined us in February 2005 as Executive Director, Planning and Administration and was promoted to Vice President of Finance in January 2006. Mr. Hamilton joined the Company from Leo Burnett USA, where he served first as controller of its U.S. subsidiaries and then successively as vice president and chief financial officer of three of its business units. Prior to joining Leo Burnett USA, Mr. Hamilton was an auditor and consultant at the Arthur Andersen and Accenture firms. He earned a master's of business administration degree from the University of Chicago's Graduate School of Business and a bachelor's degree in finance from Purdue University. Rodman P. Hise, (40) joined us in September 2000May 2001 as Manager of Corporate Communications. He was appointed Director of Corporate Communications and investor relations in April 2004 and Vice President, General CounselCorporate Affairs in October 2005. Before joining Third Wave, Mr. Hise established the in-house survey research division of a public relations firm, conducting research and Secretary. From 1998 until joining us,providing communications counsel to the Minnesota Twins Baseball Club, a major midwestern health care system and other corporate clients. He spent more than a decade serving local, state 15 and federal elected officials, including Governor Tommy G. Thompson of Wisconsin, for whom he was press secretary. Mr. Comerford was Corporate General Counsel and Secretary at Lunar Corporation,Hise earned a publicly-traded medical device company. From 1990 to 1997, Mr. Comerford was Associate Resident Counsel at National Presto Industries, Inc. Prior to 1990, Mr. Comerford was a Staff Attorney at Fort Howard Corporation. Mr. Comerford received a J.D.bachelor's degree in communication studies from Marquettethe University and a B.A. in business administration from St. Norbert College.of Iowa. REPORT OF THE AUDIT COMMITTEE The audit committee oversees the Company's financial reporting process on behalf of the board of directors. The audit committee is governed by a written charter approved by the board of directors.directors a copy of which is available on our Website at www.twt.com and attached hereto as Annex A. Management has the primary responsibility for the financial statements and the reporting process including the systems of internal controls. In fulfilling its oversight responsibilities, the audit committee reviewed with management the audited financial statements in the Company's Annual Report on Form 10-K, the unaudited financial statements in Quarterly Reports on Form 10-Q, and financial result press releases with management including a discussion of the quality, not just the acceptability, of the accounting principles, the reasonableness of significant judgments, and the clarity of disclosures in the financial statements. The audit committee reviewed with the independent auditors, who are responsible for expressing an opinion on the conformity of those audited financial statements with accounting principles generally accepted in the United States, their judgments as to the quality, not just the acceptability, of the Company's accounting principles and such other matters as are required to be discussed with the audit committee under auditing standards generally accepted in the United States. In addition, the audit committee has discussed with the independent auditors the matters required to be discussed by Statement on Auditing Standards No. 61 and the audit committee has discussed with the independent auditors the auditors' independence from management 11 and the Company including the matters in the written disclosures required by the Independence Standards Board Standard No. 1 and considered the compatibility of non-audit services with the auditors' independence. The audit committee discussed with the Company's independent auditors the overall scope and plans for their audit. The audit committee meets with the independent auditors, with and without management present, to discuss the results of their examinations, their evaluations of the Company's internal controls, and the overall quality of the Company's financial reporting. The audit committee held six meetings in 2002.2005. In reliance on the reviews and discussions referred to above, the audit committee recommended to the board of directors (and the board hasof directors approved) that the audited financial statements for the year ended December 31, 2005 be included in the Company's Annual Report on Form 10-K for the year ended December 31, 2002. The audit committee and the board have also recommended the selection of the Company's independent auditors. The foregoing report shall not be "soliciting material" or to be "filed" with the Securities and Exchange Commission, nor shall such information be incorporated by reference into any future filing under this Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, except to the extent the Company specifically incorporates it by reference into such filing.year. Respectfully submitted, The audit committee of the board of directors John Neis G. Steven Burrill Tom DanielLionel Sterling James Connelly Lawrence Murphy SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS, DIRECTORS AND MANAGEMENT The following table shows information known to us with respect to the beneficial ownership of our common stock as of April 18, 2003March 31, 2006 by: - each person (or group of affiliated persons) who owns beneficially 5% or more of our common stock; - each of our directors; - each of the Named Executive Officers; and - all of our directors and executive officers as a group. 16 Except as indicated in the footnotes to this table and subject to community property laws where applicable, the persons named in the table have sole voting and investment power with respect to all shares of our common stock shown as beneficially owned by them. Beneficial ownership and percentage ownership are determined in accordance with the rules of the Securities and Exchange Commission. Addresses for those individuals for which an address is not otherwise indicated is: c/o Third Wave Technologies, Inc., 502 South Rosa Road, Madison, Wisconsin 53719. 12
SHARES BENEFICIALLY OWNED ---------------------------------------------AMOUNT AND NATURE OF BENEFICIAL OWNERSHIP ---------------------------------------------- SHARES SUBJECT TO NAME OF BENEFICIAL OWNER TOTAL NUMBERNUMBER(1) OPTIONS PERCENTAGE - ---------------- ------------------------------------ --------------- ----------------- ---------- 5% SHAREHOLDERS: State of Wisconsin Investment Board(1)................ 5,523,000 0 13.96% Bank of America Corporation(2)........................ 3,419,450 0 8.64% NAMED EXECUTIVE OFFICERS AND DIRECTORS: Lance Fors, Ph.D.(3).................................. 2,507,816 601,770 6.24%Gordon Brunner................................. 55,000 22,500 * James Connelly................................. 277,500 -- * Kevin T. Conroy................................ 135,057 130,000 * Lawrence Murphy................................ 20,000 -- * John Puisis........................................... 293,698 275,000Neis...................................... 1,886,625(2) 56,100 4.6% Lionel Sterling................................ 28,500 7,500 * Bruce Neri, Ph.D...................................... 202,188 181,650David A. Thompson.............................. 119,300 99,300 * Maneesh Arora.................................. 277,787 259,166 * Ivan Trifunovich...................................... 52,500 52,500Trifunovich............................... 310,660 301,000 * John Comerford........................................ 69,824 48,750J. Puisis................................. 1,267,933 1,199,729 3.0% Lander Brown................................... 25,393 25,000 * Lloyd M. Smith, Ph.D.(4).............................. 2,043,600 16,800 5.16% John Neis(5).......................................... 1,837,125 16,800 4.64% David A. Thompson..................................... 58,800 58,800 * Tom Daniel(6)......................................... 1,338,426 16,800 3.38% G. Steven Burrill(7).................................. 1,047,663 16,800 2.65% Kenneth R. McGuire(2)................................. 3,119,850 16,800 7.88% Gordon F. Brunner..................................... 6,000 0 * Sam Eletr............................................. 0 0James J. Herrmann.............................. 53,048 43,750 * All directors and executive officers as a group (13(14 persons)............................................ 12,577,490 1,302,470 30.77%................................. 3,158,743 919,395 7.6% State of Wisconsin Investment Board............ 4,399,000(3) -- 10.6% Deerfield Group................................ 4,017,665(4) -- 9.7% Barclays Group................................. 2,202,674(5) -- 5.3%
- ----------------------- * indicates less than 1% (1) Based on information provided in the Schedule 13G filed by the State of Wisconsin Investment Board ("SWIB") with the SecuritiesIncludes shares currently owned and Exchange Commission on February 14, 2003. The address of SWIB is P.O. Box 7842, Madison, Wisconsin 53707.shares subject to options which are exercisable within 60 days. (2) Based on information provided in the Schedule 13G filed by Bank of America Corporation ("BAC"), NB Holdings Corporation ("NBH"), Bank of America NA ("BA"), BANA #1 LLC ("BANA") and Bank of America Strategic Solutions, Inc. ("BASS") with the Securities and Exchange Commission on February 14, 2003. The Schedule 13G reports that BANA and BASS have shared voting and dispositive power with respect to 3,417,450 of those shares, BA has sole vote and dispositive power with respect to 2,000 of those shares, and BAC and NBH have shared voting and dispositive power with respect to all 3,419,450 shares. The Schedule 13G reports that the shares reported in the Schedule are owned by Mr. McGuire and have been pledged by Mr. McGuire to BA to secure certain obligations under a loan agreement. The address of BAC is 100 N. Tryon Street, Charlotte, NC 28255. (3) Includes 1,900,800 shares of common stock held in a voting trust for the benefit of Dr. Fors' family members. Dr. Fors and his wife, Charlotte H. Selover, are co-trustees of this voting trust. (4) Includes 148,800 shares of common stock held in a voting trust for the benefit of Dr. Smith's family members. Dr. Smith is the sole trustee of this voting trust. (5) Includes 369,7871,196,550 shares held by Venture Investors of Wisconsin; 269,400445,200 shares held by Venture Investors Early Stage II Limited Partnership; 170,400 shares held by Venture Investors Early Stage Fund III Limited Partnership. (6) Includes 774,312 shares owned by Schroder Ventures International Life Sciences Fund II LPI; 329,524 shares held by Schroder Ventures International Life Sciences Fund II LPII; 88,630 shares held by Schroder Ventures International Life Sciences Fund II LPIII; 22,282 shares held by Schroder Ventures International Life Sciences Fund Group Co-Investments Scheme; 11,842 shares held by Schroder Ventures International Life Sciences Fund II Strategic Partners LP;(3) Information is as of December 31, 2005 and 25,200 shares held by Schroder Ventures Investments Limited. Mr. Daniel isbased on a manager of a company that provides consulting services to Schroder Ventures funds. Mr. Daniel disclaims beneficial ownership ofSchedule 13G filed with the shares heldSecurities and Exchange Commission by the 13 various Schroder Venture funds.State of Wisconsin Investment Board ("SWIB"). The address of Schroder VenturesSWIB is P.O. Box 7842, Madison, Wisconsin 53707. (4) Information is as of December 31, 2005 and based on a Schedule 13G filed with the Securities and Exchange Commission by Deerfield Partners, L.P. ("Partners"), a Delaware limited partnership, Deerfield Capital, L.P., a Delaware limited partnership ("Capital"), Deerfield International Life Sciences Fund II, LPI, Schroder VenturesLimited, a British Virgin Islands corporation ("International"), Deerfield Management Company, L.P., a New York limited partnership ("Management"), and Arnold Snider ("Snider"). The Schedule 13G reports that Snider has shared voting and dispositive power with respect to 4,071,665 shares, of which Capital and Partners have shared voting and dispositive power with respect to 1,758,959 shares and International Life Sciences Fund II LPII, and Schroder Ventures International Life Sciences Fund II LPIIIManagement have shared voting and dispositive power with respect to 2,312,706 shares. The address of Partners, Capital, Management and Snider is 875780 Third Avenue, 22nd37(th) Floor, New York, NY 10022-6225.New York 10017. The address of Schroder Ventures Co-Investment SchemeInternational is 22 Church Street, Hamilton HM 11, Bermuda.c/o Hemisphere Management (B.V.I.) Limited, Bison Court, Columbus Center, P.O. Box 3460, Road Town, Tortola, British Virgin Islands. (5) Information is as of December 31, 2005 and based on a Schedule 13G filed with the Securities and Exchange Commission by Barclays Global Investors, NA, Barclays Global Fund Advisors, Barclays Global Investors Japan Trust and Banking Company, Ltd. and Barclays Global Investors, Ltd. (collectively, the "Barclays Group"). The Schedule 13G reports that the Barclays Group has shared voting power with respect to 2,076,886 of these shares and shared dispositive power with respect to 2,202,674 of these shares. It does not indicate who has voting power with respect to the remaining 125,788 shares. The address of Schroder Ventures Investments Limitedthe Barclays Group is P.O. Box 255, Barfield House, St. Julian's Avenue, St. Peter Port, Guernsey GY1 4ND Channel Islands, United Kingdom. (7) Includes 1,020,863 shares held by the Burrill Agbio Capital Fund, LP. Mr. Burrill is general partner of Burrill Agbio Capital Fund, LP and disclaims beneficial ownership of these shares except to the extent of his pecuniary interest in these shares.45 Fremont Street, San Francisco, California 94105. 17 SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE Section 16(a) of the Securities Exchange Act of 1934 requires our directors and executive officers, and any persons who beneficially own more than ten percent of our common stock, to file with the Securities and Exchange Commission initial reports of ownership and reports of changes in ownership of common stock. To our knowledge, based solely on review of the copies of such reports sent to us and written representations that no other reports were required, we believe that during the year ended December 31, 2002,2005, our directors, officers and ten percent shareholdersten-percent stockholders complied with their Section 16(a) filing requirements, except that the initial statement of beneficial ownership for Dr. Eletr wasMr. Puisis filed late. SHAREHOLDERone late Form 4 reporting one transaction. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS We were not party to any reportable related party transactions in 2005. 18 STOCKHOLDER RETURN PERFORMANCE GRAPH The following graph compares the percentage change in the cumulative return on our common stock against the NASDAQ Stock Market U.S. Index (the "NASDAQ Index") and a peer group composed of the companies listed below (the "Peer Group"). The graph assumes a $100 investment on February 9, 2001 (the date of our initial public offering) in each of our common stock, the NASDAQ Index and the Peer Group and assumes that all dividends, if paid, were reinvested. This table does not forecast future performance of our common stock. (PERFORMANCE GRAPH)
- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 2/9/01 3/31/01 6/30/01 9/30/01 12/31/01 3/12/31/02 6/30/02 9/30/02 12/31/0203 12/30/04 12/31/05 - ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- TWTI 100.00 63.64 93.91 57.45 66.82 30.45 20.36 12.27 24.45 41.36 78.18 27.09 - -------------------------------------------------------------------------------------- NASDAQ 100.00 74.48 87.44 60.66 78.93 74.68 59.22 47.43 54.05 81.08 88.04 89.25 - -------------------------------------------------------------------------------------- Peer Group 100.00 53.61 65.69 37.14 62.56 39.95 28.58 18.98 19.17112.48 111.79 234.39 270.98 310.16 - --------------------------------------------------------------------------------------
14 The Peer Group consists of the following companies: Applera Corporation, Orchid Biosciences, Inc., Sequenom, Inc., Affymetrix, Inc.Gen-Probe Incorporated, Celera Diagnostics, LLC, Ventana Medical Systems, Digene, Bio-Rad Laboratories. CODE OF BUSINESS CONDUCT The Company has adopted a Code of Business Conduct (the "Code of Business Conduct") which applies to all directors, officers and Nanogen, Inc.employees. A copy of the Code of Business Conduct is available on the Company's website at www.twt.com. The foregoing graph and accompanying material shall not be "soliciting material"Company intends to make any disclosures regarding amendments to, or to be "filed" withwaivers from, the Securities and Exchange Commission, nor shallCode of Business Conduct required under Form 8-K by posting such information be incorporated by reference into any future filing under this Securities Act of 1933, as amended, oron the Securities Exchange Act of 1934, as amended, except to the extent the Company specifically incorporates it by reference into such filing.Company's website. OTHER MATTERS We know of no other matters to be submitted to the shareholdersstockholders at the meeting. If any other matters properly come before the shareholdersstockholders at the meeting, it is the intention of the persons named in the enclosed form of proxy towill vote the shares they represent as the board of directors may recommend.in their discretion. By Order of the Board of Directors, /s/ LANCE FORS, PH.D. Lance Fors, Ph.D. Chairman of the BoardKEVIN T. CONROY Kevin T. Conroy President and Chief Executive Officer Dated: April 25, 2003 15May 5, 2006 19 ANNEX A THIRD WAVE TECHNOLOGIES, INC. A DELAWARE CORPORATION CHARTER OF THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS PURPOSES The primary purpose of the Audit Committee of the Board of Directors of Third Wave Technologies, Inc., a Delaware corporation (the "Company"), is to assist the Company's Board of Directors in fulfilling its oversight responsibilities with respect to financial reports and other financial information. In this regard, the Audit Committee is to serve as the independent and objective body to make such examinations as are necessary to monitor the Company's financial reporting process and system of internal controls, to provide the Company's Board of Directors with the results of its examinations and recommendations derived therefrom, to outline to the Board of Directors improvements made, or to be made, in financial reporting process and internal accounting controls, to serve, together with the Company's Board of Directors, as the ultimate authority to which the independent auditors and the internal audit function are accountable and have, together with the Company's Board of Directors, the ultimate authority and responsibility to select, evaluate and, where appropriate, replace the independent auditors (or to nominate the independent auditors to be proposed for shareholder approval in any proxy statement), and to provide to the Board of Directors such additional information and materials as it may deem necessary to make the Board of Directors aware of significant financial matters which require the Board of Director's attention. In addition, the Audit Committee will undertake those specific duties and responsibilities listed below and such other duties as the Board of Directors may from time to time prescribe. MEMBERSHIP The Audit Committee members will be appointed by, and will serve at the discretion of, the Board of Directors and will consist of at least three members of the Board of Directors, each of whom: shall meet the applicable independence and experience requirements of the Securities and Exchange Commission, the Sarbanes-Oxley Act of 2002 and the Nasdaq Stock Market; provided that the Company's Board of Directors may, in its discretion, elect to take advantage of any applicable exceptions from such requirements. Determinations as to whether any particular director satisfies the requirements for membership on the Audit Committee will be made by the Company's Board of Directors. RESPONSIBILITIES The responsibilities of the Audit Committee shall include: 1. Reviewing the adequacy of this Charter at least annually or at such other intervals as the Audit Committee or the Company's Board of Directors determines; 2. Reviewing on a continuing basis the adequacy of the Company's financial reporting process and system of internal controls; 3. Reviewing on a continuing basis the activities, organizational structure and qualifications of the Company's internal audit function; 4. Reviewing the independent auditors' proposed audit scope and approach; 5. Conducting a post-audit review of the financial statements and audit findings, including any significant suggestions for improvements or other reports provided to management or the Audit Committee by the independent auditors and any responses to the same by management, and any significant difficulties encountered during the course of the audit; A-1 6. Reviewing any significant disagreement among management, the independent auditors and internal audit in connection with the preparation of the financial statements; 7. Reviewing with the independent auditors, internal audit and management the extent to which changes or improvements in financial or accounting practices and internal controls, as approved by the Audit Committee, have been implemented; 8. Reviewing the performance of the independent auditors, who shall be accountable to the Board of Directors and the Audit Committee; 9. Reviewing and discussing with the independent auditors all significant relationships that the auditors and their affiliates have with the Company and its affiliates in order to determine the auditor's independence; in this regard the Audit Committee shall: (1) request, receive and review, on a periodic basis, a formal written statement from the independent auditors delineating all relationships between the Company and the independent auditors that may reasonably be thought to bear on the independence of the independent auditors with respect to the Company; (2) discuss with the independent auditors any disclosed relationship or services that may impact the objectivity and the independence of the independent auditors; (3) take, or recommend that the Company's Board of Directors take, appropriate action to oversee the independence of the independent auditors; 10. Reviewing and recommending to the Board of Directors the appointment of independent auditors; 11. Reviewing and recommending to the Company's Board of Directors the fee arrangements with the independent auditors; 12. Reviewing before release the audited financial statements and Management's Discussion and Analysis in the Company's annual report on Form 10-K; 13. Reviewing before release the unaudited quarterly operating results in the Company's quarterly earnings release and the Company's quarterly financial statements and 14. Management's Discussion and Analysis in the Company's quarterly reports on Form 10-Q; 15. Reviewing and, if appropriate, approving the provision by the independent auditors of all auditing services and any non-audit services and overseeing compliance with the requirements of the Securities and Exchange Commission for independent auditor's services and disclosure of audit committee members and activities; 16. Reviewing the independent auditors' judgment about the quality and appropriateness of accounting principles as applied in financial reporting and consider and, if appropriate, recommend to the Board significant changes to auditing and accounting principles and practices as suggested by the independent auditors, management or internal audit. 17. Overseeing of compliance with the Company's Standards of Business Conduct and with the Foreign Corrupt Practices Act; 18. Establishing procedures for the receipt, retention and treatment of complaints received by the Company regarding accounting, internal accounting controls or auditing matters and for the confidential, anonymous submission by employees of the Company of concerns regarding questionable accounting or auditing matters; 19. Reviewing, in conjunction with counsel, any legal matters that could have a significant impact on the Company's financial statements; 20. Providing oversight and review of the Company's asset management policies, including an annual review of the Company's investment policies and performance for cash and short-term investments; 21. If necessary, instituting special investigations and, if appropriate, hiring special counsel or experts to assist; 22. Reviewing related party transactions for potential conflicts of interest; A-2 23. Providing a report in the Company's proxy statement in accordance with the requirements of Item 306 of Regulations S-K and S-B and Item 7(e)(3) of Schedule 14A; and 24. Performing other oversight functions as requested by the Company's Board of Directors. In addition to the above responsibilities, the Audit Committee will undertake such other duties as the Board of Directors may delegate to it and will report, at least annually, to the Board of Directors regarding the Committee's examinations and recommendations. While the Audit Committee has the responsibilities and powers set forth in this Charter, it is not the duty of the Audit Committee to plan or conduct audits or to determine that the Company's financial statements are complete and accurate and are in accordance with generally accepted accounting principles. This is the responsibility of management and the independent auditors. MEETINGS The Audit Committee will meet at least two times each year. The Audit Committee may establish its own schedule and shall provide such schedule to the Board of Directors in advance. The Audit Committee will meet separately with the Company's president and separately with the Company's chief financial officer at least annually to review the financial controls of the Company. The Audit Committee will meet separately with the independent auditors of the Company at such times as it deems appropriate to review the independent auditor's examination and management report. MINUTES The Audit Committee will maintain written minutes of its meetings, which minutes will be filed with the minutes of the meetings of the Board of Directors. ANNUAL EVALUATIONS The performance of the Committee shall be evaluated annually by the Committee members and the entire Board. A-3 THIRD WAVE TECHNOLOGIES, INC. THIS PROXY IS SOLICITED BY THE BOARD OF DIRECTORS OF THIRD WAVE TECHNOLOGIES, INC. PROXY FOR ANNUAL MEETING OF SHAREHOLDERSSTOCKHOLDERS IF NO CHOICE IS SPECIFIED, THE PROXY WILL BE VOTED "FOR" ITEMS 1THE DIRECTOR LISTED BELOW AND 2 BELOW. The undersigned shareholderstockholder of Third Wave Technologies, Inc., a Delaware corporation (the "Company"), hereby acknowledges receipt of the Proxy Statement of the Company dated April 25, 2003May 5, 2006, and hereby appoints Lance ForsKevin Conroy and John Comerford, andManeesh Arora, each of them, proxies and attorneys in fact, with full power to each of substitution, on behalf and in the name of the undersigned, to represent the undersigned at the Annual Meeting of ShareholdersStockholders of the Company to be held at the offices of the Company at 9:00 a.m. on Tuesday, June 10, 200313, 2006, and any adjournment or adjournments thereof, and to vote all shares of common stock of the Company that the undersigned would be entitled to vote if the undersigned were present, as follows: 1. The election of the following personsTo elect as directorsa director of the Company each of the nominees listed below, to serve until their successors shall be duly elected and qualified:for a term expiring at the 2009 Annual Meeting of Stockholders
NAME OF NOMINEE FOR AGAINST - ------------------------- ------------------------- ------------------------WITHHELD ------------- --- -------- Gordon F. Brunner [ ] [ ] Sam H. Eletr [ ] [ ] John NeisLawrence Murphy [ ] [ ]
For, except vote withheld from the following nominee(s): 2. To ratify the appointment of Ernst & YoungGrant Thornton LLP as independent auditorsregistered public accounting firm of the Company for the fiscal year ending December 31, 2003.2006. [ ] For [ ] Against [ ] Abstain 3. InThe undersigned shareholder(s) authorize the individuals designated to vote this proxy, to vote, in their discretion, upon any such other mattersothers (none known at the time of solicitation of this proxy) which may properly come before the meetingAnnual Meeting or any adjournmentsadjournment(s) thereof. The Board of Directors recommends a vote "FOR" each of the proposals. MARK HERE FOR ADDRESS CHANGE AND NOTE AT LEFT [ ] Grant Authority [ ] Withhold Authority THIS PROXY WILL BE VOTED IN ACCORDANCE WITH THE SPECIFIC INDICATION ABOVE. IN THE ABSENCE OF SUCH INDICATION, THIS PROXY 20 WILL BE VOTED FOR MANAGEMENT'S SLATE OF DIRECTORS AND FOR ALL OTHER ITEMS SET FORTH ABOVE AND, IN THE DISCRETION OF THE PROXYHOLDERS, ON ANY OTHER MATTERS WHICH MAY PROPERLY COME BEFORE THE MEETING OR ANY ADJOURNMENTS THEREOF. DATED: -------------------------, 2003 - -------------------------------- Signature of Shareholder - -------------------------------- PLEASE PRINT NAME(S) - -------------------------------- I plan to attend the meeting: [ ] Yes [ ] No Taxpayer Identification No. (or Social Security Number): ---------------------- Sign exactly as your name(s) appear(s) on the stock certificate(s). A corporation is requested to sign its name by its President or other authorized officer, with the office held designated. Executors, administrators, trustees, etc., are requested to so indicate when signing. If a stock is registered in two names, both should sign. SHAREHOLDERSSTOCKHOLDERS SHOULD SIGN THIS PROXY PROMPTLY AND RETURN IT IN THE ENCLOSED ENVELOPE. PLEASE RETURN ALL PAGES OF THIS PROXY PROXY. Signature: Date: Signature: Date: ------------- -------- ------------ -------